研究人员
何睿
发布时间:2019-03-25        浏览次数:1245

教授


联系方式
Email:ruihe@fudan.edu.cn

 

 


       复旦大学基础医学院免疫学教授。长期从事免疫相关炎性疾病细胞分子机制的研究,主要研究方向为粘膜免疫和肿瘤炎症的调节机制,研究成果以通讯作者或第一作者在Am J Respir Crit Care Med、Allergy、Immunity、PNAS、J Allergy Clin Immunol等国际期刊发表。科研方面获得多项国家自然基金资助,并分别获得2009年教育部“新世纪优秀人才支持计划”资助,2011年上海市“浦江人才”资助, 2013年上海市“曙光学者”以及2014年国家自然基金委“优青”。

学习和工作经历

  1. 2012.12月-至今:复旦大学上海医学院免疫学系  教授,博士生导师,课题组长

  2. 2009.11-2012.11:复旦大学上海医学院免疫学系 副研究员,博士生导师,课题组长

  3. 2004.9---2009.10:    哈佛大学波士顿儿童医院免疫学系    博士后

  4. 1999.9 ---2004.7:    中国协和医科大学   医学博士

  5. 1994.9 ---1999.7:    华西医科大学          临床医学本科   

研究方向

免疫炎症调节

代表论文 (* 通讯作者)

  1. Xiao L, Yang X, Lin Y, Li S, Jiang J, Qian S, Tang Q, He R*, Li X*. Large adipocytes function as antigen presenting cells to activate CD4+ T cells via up-regulating MHCII in obesity. Int J Obes 2015 Aug 7. [Epub ahead of print]. IF: 5.08

  2. Lv J, Zou L, Zhao L, Yang W, Xiong Y, Li B, He R*. LTB4-BLT1 axis promotes OXA-induced contact dermatitis by directing skin homing of neutrophils and CD8+ T cells. Immunology 2015 May 9. [Epub ahead of print]. IF: 3.8

  3. Wang L, Ray A, Jiang X, Wang JY, Basu S, Liu X, Qian T, He R, Dittel BN, Chu Y. T regulatory cells and B cells cooperate to form a regulatory loop that maintains gut homeostasis and suppresses dextran sulfate sodium-induced colitis. 2015 Mar 25. Mucosal Immunol [Epub ahead of print].

  4. IF: 7.54

  5. Liang M, Lv J, Zou L, Yang W, Xiong Y, Chen X, Guan M, He R*, Zou H*. A modified murine model of systemic sclerosis: bleomycin given by pump infusion induced skin and pulmonary inflammation and fibrosis.  Lab Invest. 2015 Mar;95(3):342-50. IF:3.7

  6. Li X, Xu J, Lv Z, Wang J, Sun S, Zhu W, Wang B, He R, Qu D. Inadequate activation of the HBsAg-specific Th cells by APCs leads to hyporesponsiveness to HBsAg vaccine in B10.S mice. Hum Vaccin Immunother. 2015 Jun 17:0. [Epub ahead of print]. IF: 2.4

  7. Liu WR, Tian MX1, Yang LX, Lin YL, Jin L, Ding ZB, Shen YH, Peng YF, Gao DM, Zhou J, Qiu SJ, Dai Z, He R, Fan J, Shi YH. PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma. Oncotarget. 2015 Jan 20;6(2):846-61. IF:6.4

  8. Zhao L, Yang W, Yang X, Lin Y, Lv J, Dou X, Luo Q, Dong J, Chen Z, Chu Y and He R*. Chemerin suppresses murine allergic asthma by inhibiting CCL2 production and subsequent airway recruitment of inflammatory dendritic cells. Allergy 2014 Jun;69(6):763-74. IF: 6

  9. Lin Y, Yang X, Yue W, Xu X, Li B, Zou L and He R*. Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization. Cellular & Molecular Immunol 2014 Jul;11(4):355-66. IF: 4.1

  10. Yin Q, Xu X, Lin Y, Lv J, Zhao L, and He R*. Ultraviolet B irradiation induces skin accumulation of plasmacytoid dendritic cells: A possible role for chemerin. Autoimmunity   2014 May;47(3):185-92. IF: 2.7

  11. Wang L, Zhao L, Lv J, Yin Q, Liang X, Chu Y and He R*. BLT1-dependent alveolar recruitment of CD4+CD25+ Foxp3+ regulatory T cells is important for resolution of acute lung injury. Am J Respir Crit Care Med 2012, 186(10):989-98.  IF: 13

  12. Oyoshi MK, He R (Co-first author), Li Y, Mondal, S, Yoon J, Afshar R, Chen M ,Lee DM, Luo HR, Luster AD, Cho JS, Miller LS, Larson A, Murphy GF and Geha RS. LTB4 driven neutrophil recruitment to the skin is essential for allergic skin inflammation Immunity 2012, 37(4):747-58. IF: 21.6

  13. Oyoshi MK, He R, Elkhal A, Kawamoto S, Lewis C, Kanaoka Y, Austen KF, and Geha RS. Eosinophil-derived LTC4 signals via CysLT2R to promote skin thickening and collagen deposition in a mouse model of allergic skin inflammation. Proc Natl Acad Sci U S A 2012;109(13):4992-7. IF: 9.7

  14. He R, Oyoshi MK, Wang JY, Hodge MR, Jin H, and Geha RS. The prostaglandin D(2) receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge. J Allergy Clin Immunol.  2010; 126(4):784-90. IF: 11.5

  15. He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S , Bryce P, Freyschmidt EJ, McKenzie AJ, Umetsu DT, Oettgen HC and Geha RS. Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13. J Allergy Clin Immunol 2009; 124(4):761-770.e1. IF: 11.5

  16. He R and Geha RS. Thymic Stromal Lymphopoietin. Ann N Y Acad Sci. 2010;1183:13-24. IF: 4.4

  17. Oyoshi MK, Elkhal A, Kumar L, Scott J, Koduru S, He R, Leung DY, Howell MD, Oettgen HC, Murphy GF, and Geha RS. IL-17 promotes dissemination of vaccinia virus in a mouse model of eczema vaccinatum. Proc Natl Acad Sci U S A 2009;106(35):14954-9. IF: 9.7

  18. Oyoshi MK, He R, Kumar L, Yoon J and Geha RS. Cellular and molecular mechanisms in Atopic dermatitis. Adv Immunol 2009;102:135-226. IF: 6

  19. He R, Oyoshi MK, Garibyan L, Kumar L, Ziegler SF and Geha RS. TSLP acts on infiltrating effector T cells to drive allergic skin inflammation. Proc Natl Acad Sci U S A 2008; 105(33):11875-80.

  20. IF: 9.7

  21. He R, Oyoshi MK, Jin H, Geha RS. Epicutaneous antigen exposure induces a TH17 response that drives airway inflammation after inhalation challenge. Proc Natl Acad Sci USA 2007; 104(40): 15817-22. IF: 9.7

  22. Jin H, He R ( Co-first author), Oyoshi MK, Geha RS. Animal models of atopic dermatitis. J Invest Dermatol; 2009; 129(1):31-40.  IF: 7.2

  23. Yalcindag A, He R*( Co-first author), Laouini D, Alenius H, Carroll M, Oettgen HC, Geha RS. The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen. J Allergy Clin Immunol. 2006; 117(6):1455-61. IF: 11.5

  24. Elkhal A, Pichavant M, He R, Scott J, Meyer E, Goya S, Geha RS, Umetsu DT. CD1d restricted natural killer T cells are not required for allergic skin inflammation. J Allergy Clin Immunol. 2006;118(6):1363-8. IF: 11.5

  25. Xu ZS, Liu YJ, Lv LL, Han ZB, He R, Lu SH, Wang T, Xu B, Chen ZZ, Han ZC. Bone marrow stromal cells transduced with human hemangiopoietin gene support hematopoiesis in vitro. Haematologica. 2005;90(2):157-65. IF: 5.87

  26. He R, Liu B, Yang C, Yang RC, Tobelem G, Han ZC. Inhibition of K562 leukemia angiogenesis and growth by expression of antisense vascular endothelial growth factor (VEGF) sequence. Cancer Gene Ther. 2003;10(12):879-86. IF: 2.55

著作
《间充质干细胞基础与临床》 科学出版社 2012年4月第一版,
撰写第三章 “间充质干细胞免疫调节的机制”
 

参编教材
2014年“全国高等教育医学数字化规划教材”《医学免疫学》编委

学术任职
中国免疫学会科学普及教育工作委员会     委员
中国免疫学会女科学家工作委员会         委员兼秘书
中国细胞生物学免疫细胞生物分会         委员

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