教授
联系方式
Email：dfchen@shmu.edu.cn
复旦大学药学院生药学教研室主任、教授(二级)、博士生导师。兼任国家药典委员会委员、世界中医药学会联合会中药化学/中药鉴定专业委员会副会长等多项学术职务。1986年毕业于上海医科大学药学专业，获学士学位，1991年获中国药科大学生药学博士学位，同年任教于上海医科大学，1993年晋升为副教授，1997年晋升为教授，1999年遴选为博士生导师。1990、1998年赴日本富山医科药科大学和美国阿拉巴马大学伯明翰分校学术进修，2002和2006年以访问教授身份赴美国北卡罗莱纳大学药学院和日本九州大学药学院合作研究与讲学。主要研究领域为常用中药的药效物质基础及其作用机制，在五味子科药用植物和清热解毒中药的药效物质基础研究方面具有特色。主持和完成科技部“重大新药创制”重大专项、国家杰出青年科学基金、国家自然科学基金重点项目等省部级以上科研项目30余项, 发表研究论文210余篇, 其中SCI论文120余篇, 副主编《中华人民共和国药典英文版》、《植物成分分析》和《生药学》等著作10余部，获得授权发明专利50余项。曾获得国家中医药科技进步一等奖、教育部自然科学一等奖、教育部首届青年教师奖以及国务院政府特殊津贴等奖励。教育部跨世纪人才、上海市曙光学者、上海市优秀学科带头人、国家杰出青年科学基金获得者。Elsevier中国高被引学者。
研究方向
中药药效物质基础与质量控制
代表论文
HY Zhu, XX Lu, LJ Ling, H Li, YY Ou, XL Shi, Y Lu, YY Zhang, DF Chen*. Houttuynia cordata Polysaccharides Ameliorate Pneumonia Severity and Intestinal Injury in Mice with Influenza Virus Infection. Journal of Ethnopharmacology 2018, 218: 90-99
Q Wen, Z Cao, Y Lu, DF Chen*. Anticomplement Triterpenoids from the Roots of Ilex asprella. Bioorg Med Chem Lett 2017, 27: 880-886
YY Ou, Y Jiang, H Li, YY Zhang, Y Lu, DF Chen*. Polysaccharides from Arnebia euchroma Ameliorated Endotoxic Fever and Acute Lung Injury in Rats through Inhibiting Complement System. Inflammation 2017, 40(1): 275-284
P Jiang, Y Lu, DF Chen*. Authentication of Schisandra chinensis and Schisandra sphenanthera in Chinese Patent Medicines. J Pharm Biomed Anal 2016, 131: 263-271 ( SCI)
DS Du, ZH Cheng, DF Chen*. Structure Characterization of Two Novel Polysaccharides Isolated from the Spikes of Prunella vulgaris and Their Anticomplement Activities. Journal of Ethnopharmacology 2016, 193: 345-353
M Yan, Y Lu,CH Chen,Y Zhao, KH Lee, DF Chen*. Stelleralides D–J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme. J Nat Prod 2015, 78(11): 2712-2718
LY Pan, HB Weng, H Li, ZZ Liu, YY Xu, CJ Zhou, XX Lu, Xy Su, YY Zhang, DF Chen*. Therapeutic Effects of Bupleurum Polysaccharides in Streptozotocin Induced Diabetic Mice. PLOS ONE 2015, 10(7): e0133212
YY Xu, YY Zhang, YY Ou, XX Lu, LY Pan, H Li, Y Lu, DF Chen*. Houttuynia cordata Thunb. Polysaccharides Ameliorates Lipopolysaccharide-induced Acute Lung Injury in Mice. Journal of Ethnopharmacology 2015, 173: 81-90
WH Song, ZH Cheng, DF Chen*. Anticomplement Monoterpenoid Glucosides from the Root Bark of Paeonia suffruticosa. J Nat Prod 2014, 77(1): 42-48
J Wu, YY Zhang, L Guo, H Li, DF Chen*. Bupleurum Polysaccharides Attenuates Lipopolysaccharide-induced Inflammation via Modulating Toll-Like Receptor 4 Signaling. PLOS ONE 2013, 8(10): e78051
JY Xie, H Li, HY Di, XQ Cheng, YY Zhang, DF Chen*. Bupleurum chinense DC Polysaccharides Attenuates Lipopolysaccharide-induced Acute Lung Injury in Mice. Phytomedicine 2012, 19(2): 130-137
XQ Cheng, H Li, XL Yue, JY Xie, YYZhang, HY Di, DF Chen*. Macrophage Immunomodulatory Activity of the Polysaccharides from the Roots of Bupleurum smithii var. parvifolium. Journal of Ethnopharmacology 2010, 130(2): 363-368
Q Wang, TH Chen, KF Bastow, KH Lee, DF Chen*. Altaicalarins A-D, Cytotoxic Bisabolane Sesquiterpenes from Ligularia altaica. J Nat Prod 2010, 73(2): 139-142
WH Ma, Y Lu, H Huang, P Zhou, DF Chen*. Schisanwilsonins A-G and Related Anti-HBV Lignans from the Fruits of Schisandra wilsoniana. Bioorg Med Chem Lett 2009, 19(17): 4958-4962
WH Ma, H Huang, P Zhou, DF Chen*. Schisanwilsonenes A-C, Anti-HBV Carotane Sesquiterpenoids from the Fruits of Schisandra wilsoniana. J Nat Prod 2009, 72(4): 676-678
Y Lu, DF Chen*. Analysis of Schisandra chinensis and Schisandra sphenanthera. Journal of Chromatography A 2009, 1216(11): 1980-1990
T Zhang, DF Chen*. Anticomplementary Principles of a Chinese Multiherb Remedy for the Treatment and Prevention of SARS. Journal of Ethnopharmacology 2008, 117(2): 351-361
H Xu, YY Zhang, JW Zhang, DF Chen*.Isolation and Characterization of an Anti-complementary Polysaccharide D3-S1 from the Roots of Bupleurum smithii. International Immunopharmacology 2007, 7(2):175-182
M Chen, N. Kilgore, KH Lee, DF Chen*. Rubrisandrins A and B, Lignans and Related Anti-HIV Compounds from Schisandra rubriflora. J Nat Prod 2006, 69(12):1697-1701
PL Ding, ZX Liao, H Huang, P Zhou, DF Chen*. (+)-12a-Hydroxysophocarpine, a New Quinolizidine Alkaloid and Related Anti-HBV Alkaloids from Sophora flavescens. Bioorg Med Chem Lett 2006, 16(5): 1231-1235
YQ Yu, PL Ding, DF Chen*. Determination of Quinolizidine Alkaloids in Sophora Medicinal Plants by Capillary Electrophoresis. Analytica Chimica Acta 2004, 523(1): 15-20
DF Chen*, SX Zhang, M Kozuka, QZ Sun, J Feng, Q Wang, T Mukainaka, Y Nobukuni, H Tokuda, H Nishino, HK Wang, SL Morris-Natschke, KH Lee. Interiotherins C and D, Two New Lignans from Kadsura interior and Antitumor-promoting Effects of Related Neolignans on Epstein-Barr Virus Activation. J Nat Prod 2002, 65(9):1242-1245
DF Chen*, SX Zhang, HK Wang, SY Zhang, QZ Sun, LM Cosentino and KH Lee. Novel Anti-HIV Lancilactone C and Related Triterpenes from Kadsura lancilimba. J Nat Prod 1999, 62(1): 94 -97
DF Chen*, SX Zhang, L Xie, JX Xie, K Chen, Y Kashiwada, BN Zhou, P Wang, LM Cosentino and KH Lee. Anti-AIDS Agents 26. Structure-Activity Correlations of Gomisin G-Related Anti-HIV Lignans from Kadsura interior and of Related Synthetic Analogues. Bioorg Med Chem 1997, 5(8):1715-1723
DF Chen*, SX Zhang, K Chen, BN Zhou, P Wang, LM Cosentino and KH Lee. Two New Lignans, Interiotherins A and B, as Anti-HIV Principles from Kadsura interior. J Nat Prod 1996, 59(11): 1066-1068
联系方式：电话：021-51980135；电子信箱：dfchen@shmu.edu.cn