研究人员
魏园园
发布时间:2019-03-25        浏览次数:606

研究员


联系方式
Tel: +86-21-54237730
Email:  ywei@fudan.edu.cn
地址:上海市徐汇区东安路130号13号楼,200237 上海

 


研究方向
       动脉粥样硬化引起的心脑血管疾病已成为世界上致死率最高的疾病之一,但由于发病机制的复杂性,对于这种慢性炎症疾病的预防与治疗在国际上仍旧是一个难题。巨噬细胞在血管内膜下的积累是造成动脉粥样硬化发展的主要原因,基于动脉粥样硬化斑块内巨噬细胞的表型呈现异质性和可塑性的特点,本人的研究聚焦动脉粥样硬化过程中巨噬细胞的代谢变化、极性活化以及血管内膜通透性及其调节机制,特别是microRNA在这些过程中的作用与功能,旨在发现新型心血管药物的靶点。

代表论文

  1. Wei Y*, Gurung R, Corbalán-Campos J, Natarelli L, Exner N, Erhard F, Greulich F, Zhu M, Geißler C, Uhlenhaut NH, Zimmer R, Schober A*. Dicer in Macrophages Prevents Atherosclerosis by Promoting Mitochondrial Oxidative Metabolism. Circulation. 2018; 138(18):2007-2020. *co-corresponding author. (Impact factor: 18.9)

  2. Wei Y#, Nazari-Jahantigh M#, Chan L, Zhu M, Heyll K, Corbalán-Campos J, Hartmann P, Thiemann A, Weber C, Schober A. The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis. Circulation. 2013;127(15):1609-1619. #co-first author. (Impact factor: 18.9)

  3. Wei Y, Zhu M, Corbalán-Campos J, Heyll K, Weber C, Schober A. Regulation of Csf1r and Bcl6 in macrophages mediates the stage-specific effects of microRNA-155 on atherosclerosis. Arterioscler Thromb Vasc Biol. 2015;35(4):796-803. (Impact factor: 6.1)

  4. Wei Y, Chen S, Yang P, Ma Z, Kang L. Characterization and comparative profiling of the small rna transcriptomes in two phases of locust. Genome biology. 2009;10:R6. (Impact factor: 13.2)

  5. He J #, Chen Q#, Wei Y#, Jing F, Yang M, Hao S, Guo X, Chen D, Kang L. MicroRNA-276 promotes egg hatching synchrony by upregulating brm in locusts. Proc Natl Acad Sci U S A. 2016;113(3):584-9. (Impact factor: 9.5). #co-first author.

  6. Yang M#, Wei Y#, Jiang F#, Wang Y, Guo X, He J, Kang L. MicroRNA-133 inhibits behavioral aggregation by controlling dopamine synthesis in locusts. PLoS Genet, 2014;10(2):e1004206. #co-first author. (Impact factor: 5.5) (Recommended in F1000Prime (http://f1000.com/prime/718293925))

  7. Wei Y, Schober A. MicroRNA regulation of macrophages in human pathologies. Cell Mol Life Sci. 2016; 73(18): 3473-95. (Impact factor: 6.7)

  8. Wei Y, Zhu M, Schober A. Macrophage MicroRNAs as Therapeutic Targets for Atherosclerosis, Metabolic Syndrome, and Cancer. Int J Mol Sci. 2018;19(6). (Impact factor: 3.7)

  9. Wei Y, Schober A, Weber C. Pathogenic arterial remodeling: The good and bad in micrornas. Am J Physiol Heart Circ Physiol. 2013;304:H1050-9. (Impact factor: 3.6)

  10. Wei Y, Nazari-Jahantigh M, Neth P, Weber C, Schober A. Microrna-126, -145, and -155:  A therapeutic triad in atherosclerosis? Arterioscler Thromb Vasc Biol. 2013;33:449-454.  (Impact factor: 6.1)

  11. Natarelli L, Geißler C, Csaba G, Wei Y, Zhu M, di Francesco A, Hartmann P, Zimmer R, Schober A. Nat Commun. 2018;9(1):2645. (Impact factor: 12.4)

  12. Zhu M, Wei Y, Geißler C, Abschlag K, Corbalán Campos J, Hristov M, Möllmann J, Lehrke M, Karshovska E, Schober A. Hyperlipidemia-Induced MicroRNA-155-5p Improves β-Cell Function by Targeting Mafb. Diabetes. 2017 66(12):3072-3084. (Impact factor: 7.3)

  13. Zahedi F, Nazari-Jahantigh M, Zhou Z, Subramanian P, Wei Y, Grommes J, Offermanns S, Steffens S, Weber C, Schober A. Dicer generates a regulatory microRNA network in smooth muscle cells that limits neointima formation during vascular repair. Cell Mol Life Sci. 2017;74(2):359-372. (Impact factor: 6.7)

  14. Hartmann P, Zhou Z, Natarelli L, Wei Y, Nazari-Jahantigh M, Zhu M, Grommes J, Steffens S, Weber C, Schober A. Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4. Nat Commun. 2016;7:10521. (Impact factor: 12.4)

  15. Schober A#, Nazari-Jahantigh M#, Wei Y, Bidzhekov K, Gremse F, Grommes J, Megens RT, Heyll K, Noels H, Hristov M, Wang S, Kiessling F, Olson EN, Weber C. MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1.  Nat Med. 2014;20(4):368-76. (Impact factor: 32.6) (Recommended in F1000Prime (http://f1000.com/prime/718293958))

  16. Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J Clin Invest. 2014;124(5):2136-46. (Impact factor: 13.3)

  17. Nazari-Jahantigh M, Wei Y, Noels H, Akhtar S, Zhou Z, Koenen RR, Heyll K, Gremse F, Kiessling F, Grommes J, Weber C, Schober A. Microrna-155 promotes atherosclerosis by repressing bcl6 in macrophages. J Clin Invest. 2012;122:4190-4202. (Impact factor: 13.3)

  18. Nazari-Jahantigh M, Wei Y, Schober A. The role of micrornas in arterial remodelling.  Thromb Haemost 2012;107:611-618. (Impact factor: 5)

  19. Wang Y, Jiang F, Wang H, Song T, Wei Y, Yang M, Zhang J, Kang L. Evidence for the expression of abundant microRNAs in the locust genome. Sci Rep. 2015;5:13608. (Impact factor: 4.1)

  20. Chen S, Yang P, Jiang F, Wei Y, Ma Z, Kang L. De novo analysis of transcriptome dynamics in the migratory locust during the development of phase traits. PLoS One. 2010;5(12):e15633. (Impact factor: 2.8)

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